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Full list of publications

Koponen E, Rantamäki T, Võikar V, Saarelainen T, MacDonald E and Castrén E: Enhanced BDNF signaling is associated with changes in brain monoamines and induces an antidepressant-like behavioral response. Cellular and Molecular Neurobiology 25:973-80, 2005.

Rantamäki T, Knuuttila J, Hokkanen M-E and Castrén E: The effects of acute and long-term lithium treatments on trkB neurotrophin receptor activation in mouse hippocampus and anterior cingulate cortex. Neuropharmacology50:421-7, 2006.


Castrén E, Võikar V and Rantamäki T:  Role of neurotrophic factors in depression. Current Opinion in Pharmacology 7:18-21, 2007.

Rantamäki T, Hendolin P, Kankaanpää A, Mijatovic J, Piepponen P, Domenici E, Chao M, Männistö P and Castrén E: Pharmacologically diverse antidepressants rapidly activate Brain-derived neurotrophic factor (BDNF) receptor TrkB and induce phospholipase-Cγ1 signaling pathways in mouse brain. Neuropsychopharmacology 32:2152-62, 2007.

Hansen HH*, Rantamäki T*, Larsen MH, Woldbye D, Mikkelsen JD and Castrén E: Rapid activation of extracellular signal-regulated kinase (ERK) signaling in the rat medial prefrontal cortex is not mediated by TrkB neurotrophin signaling. Cellular and Molecular Neurobiology 27:585-594, 2007. * equal contribution


Perga S, Martin MG, Trovo L, Rasola A, Holm P, Rantamäki T, Harkany T, Castrén E, Chiara F and Dotti CG:Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro. Molecular Biology of the Cell19:2101-12, 2008.

Rantamäki T and Castrén E: Targeting TrkB receptor to treat depression. Expert Opinion on Therapeutic Targets12:705-15, 2008.


Sallert M, Rantamäki T, Vesikansa A, Anthoni H, Harju K, Yli-Kauhaluoma J, Taira T, Castrén E and Lauri S: BDNF controls activity-dependent maturation of CA1 synapses by down regulating tonic activation of presynaptic kainate receptors. Journal of Neuroscience 29:11294-303, 2009.


Castrén E and Rantamäki T: Role of Brain-Derived Neurotrophic Factor in the Etiology of Depression: Implications for Pharmacological Treatment. CNS Drugs 24:1-7, 2010.

Castrén E and Rantamäki T: The role of BDNF and its receptors in depression and the antidepressant drug action: reactivation of developmental plasticity. Developmental Neurobiology 70:289-97, 2010.

Gyarfas T, Knuuttila J, Lindholm P, Rantamäki T and Castrén E: Regulation of Brain-Derived Neurotrophic Factor (BDNF) and Conserved Dopamine Neurotrophic Factor (CDNF) by Anti-parkinsonian Drug Therapy In Vivo.Cellular and Molecular Neurobiology 30:361–368, 2010.

Spulber S, Rantamäki T, Nikkilä O, Castrén E, Weihe P, Grandjean P and Ceccatelli S: Effects of maternal smoking and exposure to methylmercury on Brain-Derived Neurotrophic Factor (BDNF) concentrations umbilical cord serum.Toxicological Sciences 117:263-9, 2010.

Karpova N*, Rantamäki T*, DiLieto A, Lindemann L, Hoener M and Castrén E: Darkness reduced BDNF expression in the visual cortex and induces repressive chromatin remodeling at the BDNF gene in both hippocampus and visual cortex. Cellular and Molecular Neurobiology 30:1117-23, 2010. * equal contribution


Louhivuori V, Vicario A, Uutela M, Rantamäki T, Louhivuori L, Castrén E, Tongiorgi E, Åkerman K and Castrén M: BDNF and TrkB in neuronal differentiation of Fmr1 –knockout mouse. Neurobiology of Disease 41:469-80, 2011.

Kaste K, Kivinummi T, Rantamäki T, Castrén E and Ahtee L: Long-term adaptative changes on BDNF and phospho-CREB levels following chronic oral nicotine treatment and its withdrawal in dopaminergic brain areas of mice. Neuroscience Letters 491:108-12, 2011.

Razzoli M, Domenici E, Carboni L, Rantamäki T, Lindholm J, Castrén E and Arban R: A role for BDNF/TrkB.T1 signaling in long-term behavioral and physiological consequences of social defeat stress. European Journal of Neuroscience 10:424-33, 2011.

Rantamäki T, Vesa L, Antila H, Di Lieto A, Tammela P, Schmitt A, Rios M, Lesch KP and Castrén E: Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade. PLoS One 6:e20567, 2011.

Autio H, Mätlik K, Rantamäki T, Lindemann L, Hoener MC, Chao M, Arumäe U, Castrén E: Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus. Neuropharmacology 61:1291-6, 2011.


Lindholm J, Autio H, Vesa L, Antila H, Lindemann L, Hoener MC, Rantamäki T, Skolnick P and Castrén E: The antidepressant-like effects of glutamatergic drugs are preserved in bdnf+/- heterozygous null mice.Neuropharmacology 62:391-7, 2012.

Di Lieto A*, Rantamäki T*, Vesa L, Sudhirkumar Y, Antila H, Lindholm J, Rios M, Tessarollo L, and Castrén E: Contrasting postnatal regulation of TrkB autophosphorylation and signalling by antidepressants and BDNF. PLoS One 7:e32869, 2012. *equal contribution

Kemppainen S, Rantamäki T, Jerónimo-Santos A, Lavasseur G, Autio H, Karpova N, Kärkkäinen E, Stavén A, Miranda HV, Outeiro TF, Diógenes MJ, Laroche S, Davis S, Sebastião AM, Castrén E and Tanila H: Contribution of TrkB receptor signaling on the neurological phenotype of APP/PS1 transgenic mouse model of Alzheimer´s disease.Neurobiology of Aging 33:1122.e23-39, 2012.

Savelyev SA, Rantamäki T, Rytkönen KM, Castrén E and Porkka-Heiskanen T: Effect of sleep deprivation on sleep homeostasis in a rodent clomipramine model of depression. Neuroscience 212:149-58, 2012.


Rantamäki T, Kemppainen S, Autio H, Stavén S, Koivisto H, Kojima M, Antila H, Miettinen PO, Kärkkäinen E, Vesa L, Karpova N, Lindemann L, Hoener MC, Tanila H and Castrén E: The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer’s disease. PLoS One3;8(7):e68722, 2013.


Antila H, Autio H, Turunen L, Harju K, Tammela P, Wennerberg K, Yli-Kauhaluoma J, Huttunen HJ, Castrén E and Rantamäki T: Utilization of in situ ELISA methodology for examining Trk receptor phosphorylation in cultured cells. Journal or Neuroscience Methods 222:142-146, 2014.

Thakker-Varia S, Behnke J, Doobin D, Dalal V, Thakkar K, Khadim F, Wilson E, Antila H, Rantamäki T and Alder J: VGF-induced Neurogenesis Targets Early Phase Neural Progenitor Cells in the Adult Hippocampus and Requires Glutamate Signaling. Stem Cell Research 12:762-777, 2014.

Uutela M, Lindholm J, Rantamäki T, Umemori J, Hunter K, Võikar V and Castrén M: Distinctive behavioral and cellular responses to fluoxetine in the mouse model for fragile X syndrome, a variant of autism spectrum disorder.Frontiers in Neuroscience, 8:150, 2014.


Koskimäki J, Matsui N, Umemori J, Rantamäki T and Castrén E: Nimodipine activates TrkB neurotrophin receptors and induces neuroplastic and neuroprotective signaling events in the mouse hippocampus and prefrontal cortex.Cellular and Molecular Neurobiology 2:189-96, 2015.

Aonurm-Helm A, Anier K, Zharkovsky T, Castrén E, Rantamäki T, Stepanov V, Järv J and Zharkovsky A: NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in brain – restoration by chronic amitriptyline. European Neuropsychopharmacology 12:2394-403, 2015.


Rantamäki and Yalcin: Antidepressant drug action – from rapid changes on network activity to network rewiring.Progress in Neuro-Psychopharmacology & Biological Psychiatry, 64:285-292, 2016.

Kohtala S, Suomi T, Theilmann W, Wigren H-K, Stenberg T, Elo LL, Rokka A and Rantamäki T: Brief isoflurane anesthesia produces prominent phosphoproteomic changes in the adult mouse hippocampus. ACS Chemical Neuroscience 6:749-56, 2016.


Rantamäki T: Masennuslääkkeet edistävät hermoverkkojen muovautuvuutta – mitä hyötyä siitä on aivoille?Lääkärilehti 68:2675-2680, 2013.

Rantamäki T: Lääke antaa masentuneelle mahdollisuuden. Tiede 33:52-55, 2013.

Rantamäki T: Fiksuja masennuslääkkeitä. Blogikirjoitus, 2016. Osta Viagra osta viagra suomessa köp viagra snabb leverans köp viagra receptfritt Osta Viagra ilman reseptiä. Viagra hinta